Frequently Asked Questions
For immediate product support, please contact:
Global Product Manager
Director of Membrane and Applications
Quality Assurance Manager
Concentration of Myeloma Cells
The objective of the study, summarized in AN1001, was to concentrate myeloma cells using tangential flow filtration (TFF) prior to downstream processing. The following text outlines a case study performed at the Massachusetts Institute of Technology (MIT), demonstrating the effectiveness of using the NovaSet-LS™ LHV tangential flow filtration device.
Cassette Air Integrity Testing
The purpose of cassette integrity testing is to provide a non-destructive method to verify the integrity of a Tangential Flow Filtration (TFF) cassette. Each cassette manufactured by TangenX undergoes strict release testing, which includes an air integrity test. Application note AN1002 is available for download to help our customers understand the basic fundamentals and importance of “in-field” integrity testing. Please click the link above or to your right to download AN1002.
TFF Cassette Cleaning and Storage
TFF cassette cleaning and storage is a key priority when using conventional TFF cassettes. A repeatable CIP (clean in place) cycle is used to remove residual contaminants from the TFF cassettes following each use. A documented membrane CIP cycle is used to maximize product recovery, batch to batch consistency, membrane recovery, and membrane productivity. Application note AN1004 is available for download to help our customers develop a written procedure for cassette cleaning. Please click the link above or to your right to download AN1004.
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